The Warrego Highway between Roma and Mungallala has reopened after being cut off earlier this morning by floodwaters.
The Department of Transport and Main Roads closed the road 21 kilometres west of Mitchell at the first crossing of Big Womalilla Creek in both directions at about 9am.
TMR has since assessed the flooded areas and deemed the road able to be reopened.
"The rain has held off for a few hours now, and the TMR staff have assessed the flooded roads," regional director Kym Murphy said.
"Staff have decided it is now safe to reopen the highway."
The Bureau of Meteorology recorded 48mm of rain in Roma between Tuesday morning and Wednesday morning, with Mitchell receiving 50mm and Injune 35mm.
Heavier falls were experienced in the headwaters to the north of Mitchell with the creeks flowing over the Womblebank Gap Road, west of Injune.
Rain is expected to continue into the evening, with the upper lower pressure system set to weaken overnight.
According to the BoM's forecast, the wet conditions will ease heading into the weekend.