Ahead of a meeting with commonwealth's national security committee, Premier Palaszczuk warned of more lockdowns if Australia does not better prepare for the future.
Masks will no longer required to be carried and visitor restrictions at hospitals, aged care facilities and prisons will be scrapped.
A tourism push for Australian's to fill the void of international travel saw many operators fill bookings with travellers prepared to spend millions across the state
Two separate clusters, both originating from the Princess Alexandra Hospital, have been responsible for the outbreak and subsequent Brisbane lockdown.
"I don't think it matters whether you're in Gladstone or Toowoomba or Gold Coast - it's anywhere in Queensland, because people have been very, very mobile since March 20."
Mask rules will be in place across the state until April 15, Queensland Premier Annastacia Palaszczuk said.